About

The International PSC Study Group

The International PSC Study Group (IPSCSG) was founded in Oslo in 2010 to coordinate primary sclerosing cholangitis research across leading institutions worldwide. More than twenty countries are represented.

Its purpose is to align research topics between groups so that studies complement one another instead of competing or duplicating effort. That alignment lets projects reach a size at which robust conclusions become possible — something few single centres can achieve alone in a disease this rare.

Both basic science and clinical groups take part, which makes translational work feasible that would otherwise not be. A joint database for patient data underpins several ongoing studies.

Steering committee

• Christoph Schramm, Hamburg, Germany Secretary
• Ansgar W. Lohse, Hamburg, Germany Secretary
• David Assis, Yale University, USA
• Nora Cazzagon, Padova, Italy
• Aliya Gulamhusein, Toronto, Canada
• Cara Mack, Wisconsin, USA
• Bregje Mol, Amsterdam, The Netherlands
• Palak Trivedi, Birmingham, UK
• Mette Vesterhus, Bergen, Norway

ipscsg.org →

The Resnek Family Center for PSC Research

The Resnek Family Center for Primary Sclerosing Cholangitis (PSC) Research grew from something deeply personal. When Frank and Barbara Resnek’s grandson was diagnosed with PSC, their family was confronted with the realities of a rare and unpredictable disease for which there are still no approved medical therapies. Determined to help change that future—not only for their own family, but for people and families affected by PSC everywhere—the Resneks made an extraordinary commitment to advancing PSC research.

In 2019, Frank and Barbara established the Resnek Family Center for PSC Research at Brigham and Women’s Hospital, now part of Mass General Brigham, ultimately committing $45 million to accelerate the search for effective treatments. Under the direction of Joshua Korzenik, MD, the center has supported investigators and innovative projects, developed patient cohorts and biospecimen resources, and pursued new approaches to understanding the biology of PSC and translating discoveries into better care.

From the beginning, the Resneks have understood that progress against a disease as complex as PSC will require collaboration well beyond any single laboratory, institution, or country. That philosophy continues to shape the center today. The Resnek Center seeks to bring people and ideas together, support promising science, and work alongside the broader international PSC community to accelerate progress for patients.

It is in that spirit that the Resnek Center is honored to host the 2026 International PSC Study Group Biennial Meeting in Boston and to support the exchange of ideas, new collaborations, and shared commitment represented by everyone gathered here.